Reta Peptide, Research Grade Triple Agonist (GIP / GLP-1 / Glucagon), ≥99% HPLC Purity
Reta (also searched as reta peptide, RETA research peptide, or developmental identifier LY3437943) is an engineered 39-amino acid acylated unimolecular peptide designed as a highly potent triple receptor agonist targeting GIP, GLP-1, and Glucagon (GCG) receptors. In preclinical research contexts, this extensive multi-receptor profile supports controlled evaluation of complex metabolic signaling and co-activation kinetics in high-sensitivity laboratory models.
Available Strengths
Common protocol targets include reta 10mg, reta 20mg, and reta 30mg. Choose the exact concentration profile that matches your active institutional documentation requirements.
Product Details
- Weight: 0.02 lbs
- Dimensions: 1.5 × 2.75 × 1 in
- Format: Lyophilized White Powder (Sealed Sterile Vial)
- Strengths: 10 mg / 15 mg / 20 mg / 30 mg
Shipping & Logistics
Shipping Destination: USA only (Maintained in sub-zero cold-chain archives prior to dispatch).
- Economy Shipping: $9.99 — estimated delivery 5–8 business days
- Standard Shipping: $18.99 — estimated delivery 3–4 business days

What Is Reta? Structural Blueprint & Acylation
A frequent query in biochemical databases is “what is reta”. Reta is a synthetic unimolecular peptide comprising a 39-amino acid sequence. Its primary sequence is derived from the GIP backbone but engineered to introduce glucagon and GLP-1 receptor activity. Crucially, the structure incorporates a C20 fatty diacid moiety that facilitates albumin binding in laboratory models, protecting the peptide from immediate enzymatic cleavage and extending its reported half-life to approximately 6 days. For a comprehensive overview, see: Reta Peptide: Structure, Classification & Research Overview.
Reta Mechanism of Action & Tuned Potency Hierarchy
In controlled research settings, the reta mechanism of action centers on its "Triple Synergy" profiles. Unlike traditional compounds, it exhibits a specifically tuned potency hierarchy across its targets:
- Robust GIP Affinity: Optimized to drive complex lipid buffering and cellular homeostasis studies.
- Moderate GLP-1 Activation: Tailored for precise satiety-related signaling pathway mapping.
- Balanced Glucagon Co-Activation: Specifically tuned to drive energy expenditure pathways without inducing transient hyperglycemia.
For a related structural classification guide, see: Is Reta a Steroid? Structural Classification & Mechanism of Action.
Advanced Sourcing Benchmarks: Reta vs. Competitors
Direct comparative validation of reta vs tirz and sema is a primary focal point in modern metabolic trials. Sourcing a true triple-agonist allows researchers to analyze energy intake and hepatic defatting parameters simultaneously—capabilities that single or dual-agonist vectors cannot replicate. For a deep-dive comparison, read: Reta vs Tirz — Key Research Differences.
Comparative Efficacy Profile Matrix:
| Parameter Target | Reta (Triple Agonist) | Tirz (Dual Agonist) | Sema (Mono Agonist) |
|---|---|---|---|
| Mechanism Target | GIP / GLP-1 / Glucagon | GIP / GLP-1 | GLP-1 |
| Mean Weight Red. (High Dose)* | ~24% – 29% (Phase 3 data) | ~21% | ~15% |
| Hepatic Fat Normalization Rate* | >86% (Hepatic Defatting) | Moderate | Low |
| Primary Signaling Focus | Appetite paths + Active caloric burn | Appetite suppression mapping | Appetite suppression mapping |
*Data indicators sourced from recent peer-reviewed Phase 2/3 clinical trial registries (including the TRIUMPH and TRANSCEND research series 2025-2026) for comparative evaluation only.
Product Specifications
| Product Name | Reta (Research Grade) |
|---|---|
| Label / Chemical Identifier | RETA / LY3437943 |
| CAS Number | 2381089-83-2 |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | ~4731 g/mol |
| Target Receptors | GIP / GLP-1 / Glucagon (GCG) |
| Purity Level | ≥99% (HPLC verified; per lot CoA) |
| Solubility Profile | Soluble in sterile water or bacteriostatic water |
| Endotoxin Level | < 1.0 EU/mg (Screened to ensure suitability for high-sensitivity assays) |
Quality Control & Lot Documentation (CoA)
Each synthesis batch includes a rigorous Certificate of Analysis (CoA) ensuring strict lot/batch traceability. Purity profiles are verified by high-absorbance HPLC and structural identity is authenticated via mass spectrometry to guarantee absolute data integrity and eliminate variables f research workflows. For procurement evaluation benchmarks, see: Where to Buy Reta for Research Purposes.
Reconstitution Mathematics & Handling Protocols
Prior to laboratory execution, determine your exact target dilution volumes using the standard volumetric concentration equation:
$V = \frac{m}{C}$
Where $V$ is the required solvent volume (mL), $m$ is the total peptide mass in the vial (mg), and $C$ is the targeted protocol concentration (mg/mL).
- Lyophilized storage: Store in deep freeze conditions at −20°C (or as stated on lot CoA) for long-term preservation.
- Reconstituted solutions: Use sterile, premium bacteriostatic water to maintain solution stability. Store at 2°C to 8°C and protect from direct thermal stress or light exposure.
- Avoid: Repeated freeze–thaw cycles and strong physical agitation; introduce solvents slowly down the vial wall to prevent sequence shearing.
Frequently Asked Questions (FAQ)
What is reta peptide?
Reta peptide is an investigational 39-amino acid synthetic peptide studied for triple-agonist receptor signaling (GIP/GLP-1/Glucagon) f multi-pathway metabolic research. It is referenced in scientific literature as RETA or LY3437943.
Why is mass spectrometry verification critical for Reta sourcing?
HPLC only validates relative chemical purity profiles based on retention time. Independent mass spectrometry mapping is mandatory to confirm the specific molecular mass (~4731 g/mol) and verify the presence of the critical C20 fatty acid side chain responsible for its extended stability profile.
Is Reta FDA approved?
No. Reta is not FDA approved and is supplied exclusively as a research-use-only (RUO) chemical compound for laboratory trials.
Is Reta a peptide or a steroid?
Reta is an amino acid-based synthetic peptide polymer and completely lacks a steroid ring structure.
Reta vs tirz — what’s the primary operational difference?
In metabolic models, reta operates through a unique triple-hormone co-activation mechanism (GIP / GLP-1 / Glucagon), whereas tirz acts exclusively as a dual agonist targeting only the GIP and GLP-1 receptors.
How does Reta safely balance potent Glucagon signaling?
The sequence is engineered with a tuned potency ratio where the high insulinotropic actions mediated by GIP and GLP-1 activation effectively counterbalance glucagon signaling, preventing downstream hyperglycemia downsides f laboratory subjects.