Tesamorelin Peptide – High Purity Research Reagent
Introduction to Tesamorelin Peptide
Tesamorelin peptide is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH), extensively studied for its potent ability to stimulate the synthesis and release of endogenous growth hormone (GH). Unlike native GHRH, tesamorelin incorporates an N-terminal trans-3-hexenoyl modification, which significantly enhances its stability and resistance to enzymatic degradation in biological systems.
At Peptides Skin, we supply premium-grade, lyophilized tesamorelin designated strictly as a research reagent. Each lot is manufactured to >99% purity and verified by High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to support reproducible scientific results.
Technical Specifications
| Property | Details |
|---|---|
| Chemical Name | Tesamorelin Acetate |
| CAS Number | 218949-48-5 |
| Molecular Formula | C221H366N72O67S |
| Molecular Weight | 5135.9 g/mol (free base) |
| Purity | ≥ 99.0% (HPLC) |
| Form | Lyophilized white powder |
| Sequence | Trans-3-hexenoyl-[Tyr1]hGRF(1–44)NH2 |
What Is Tesamorelin?
Tesamorelin is a 44-amino-acid peptide that functions as a growth hormone-releasing factor (GRF) analog. It closely mimics the full-length sequence of human GHRH with an added trans-3-hexenoyl group at the N-terminal tyrosine residue, a modification that improves its plasma stability and half-life in research models.
In clinical literature, tesamorelin has been investigated extensively, and proprietary drug products containing tesamorelin have received regulatory approval for specific indications. However, the material offered in our research peptide catalog is supplied only as a research reagent for in vitro and non-clinical in vivo studies and is not a finished pharmaceutical preparation.
At the mechanistic level, tesamorelin binds to GHRH receptors in the pituitary, promoting the pulsatile release of endogenous growth hormone and subsequent modulation of downstream mediators such as IGF-1. This makes it a valuable tool for exploring somatotropic axis physiology and metabolic regulation in controlled research settings.
Key Research Applications
Tesamorelin is frequently selected by researchers studying metabolic peptides and growth hormone pathways. Common preclinical and experimental applications include:
1. Visceral Adipose Tissue (VAT) and Body Composition Models
Research has highlighted tesamorelin as a probe for selectively targeting visceral adipose tissue (VAT) in experimental systems. VAT is metabolically active and strongly associated with insulin resistance and cardiometabolic risk. In such models, tesamorelin is used to examine how GHRH analogs may influence VAT mass, adipokine profiles, and overall body composition.
2. Growth Hormone Secretion Dynamics
Because tesamorelin stimulates endogenous GH release instead of providing exogenous recombinant HGH, it is widely used to study the somatotropic axis under more physiological conditions. Investigators monitor GH and IGF-1 responses, feedback regulation, and the preservation of circadian or diurnal secretion patterns.
3. Lipid Profiles and Metabolic Health
Scientific literature also explores how tesamorelin exposure may affect lipid parameters such as triglycerides and cholesterol in research models. These experiments support investigations into dyslipidemia, metabolic syndrome, and GH-related modulation of lipid metabolism.
Structure and Stability
The defining structural feature of tesamorelin is the trans-3-hexenoyl group attached to the N-terminal tyrosine of the hGRF(1–44) backbone. This modification increases resistance to degradation by dipeptidyl peptidase IV (DPP-IV) and other plasma enzymes, extending the peptide’s functional half-life compared with native GHRH derivatives such as sermorelin.
This enhanced stability, combined with high purity, makes tesamorelin a robust candidate for cell-based assays, receptor-binding experiments, and in vivo proof-of-concept studies where consistent exposure profiles are essential.
Storage and Handling
To preserve peptide integrity and performance, researchers should follow standard peptide handling practices:
- Lyophilized Powder: Store at −20 °C or below, protected from light and moisture. Under these conditions, tesamorelin is typically stable for up to 24 months.
- Reconstituted Solution: After reconstitution with bacteriostatic water or sterile saline, store at 4 °C and use within 1–2 weeks, depending on solvent and laboratory protocols.
- Handling: Avoid repeated freeze–thaw cycles. Aliquot solutions where possible to minimize degradation.
Note: Tesamorelin is supplied as a lyophilized powder. Solvents for reconstitution are not included.
Why Choose Peptides Skin for Tesamorelin?
As a trusted B2B supplier, Peptides Skin focuses on delivering high-purity research peptides with full analytical transparency. We understand that reproducible data depend on consistent reagent quality.
- High Purity: Every batch of tesamorelin is tested to confirm >99% purity by HPLC.
- Documented Quality: Certificates of Analysis (CoA) and supporting analytical data are available to qualified research clients.
- Secure Shipping: Packaging and logistics are optimized to maintain stability during transit.
- Dedicated Support: Technical assistance is available for institutional and laboratory partners.
Safety & Research Disclaimer
⚠ WARNING: RESEARCH USE ONLY — NOT FOR HUMAN OR VETERINARY CONSUMPTION.
Products offered by Peptides Skin, including tesamorelin, are intended solely for laboratory research, in vitro testing, and chemical analysis. They are not approved as drugs, foods, cosmetics, or dietary supplements. Nothing in this description is intended as medical or therapeutic advice.
Frequently Asked Questions about Tesamorelin
Is Tesamorelin the same as natural GHRH?
Tesamorelin is an analog of human GHRH, meaning it closely resembles the endogenous peptide but includes additional structural modifications—notably an N-terminal trans-3-hexenoyl group—to enhance stability and half-life in research models.
What is the primary research use of Tesamorelin?
Tesamorelin is primarily used to study growth hormone secretion dynamics, visceral adipose tissue models, and metabolic regulation. It allows researchers to stimulate endogenous GH release and monitor downstream effects on IGF-1, lipid profiles, and body composition in controlled experimental systems.
How should Tesamorelin peptide be stored?
Lyophilized tesamorelin should be stored at −20 °C or below, protected from light and moisture. After reconstitution in an appropriate solvent, it is generally kept at 4 °C and used within 1–2 weeks, avoiding repeated freeze–thaw cycles.
Is Tesamorelin from Peptides Skin suitable for human therapy?
No. Tesamorelin supplied by Peptides Skin is labeled strictly for research use only. It is not a pharmaceutical product and is not intended or approved for human or veterinary therapy, self-administration, or diagnostic applications.