Ipamorelin Peptide (Research Grade) – >99% Purity
Introduction to Ipamorelin Peptide
Ipamorelin peptide is a synthetic pentapeptide and a highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R1a). It is extensively utilized in laboratory studies focusing on growth hormone (GH) pulsatility, metabolic regulation, and recovery-related pathways. Distinct from several other Growth Hormone Releasing Peptides (GHRPs), pre-clinical literature reports that Ipamorelin stimulates GH release with minimal impact on cortisol or prolactin levels.
At Peptides Skin, we provide premium, lyophilized Ipamorelin intended strictly for in vitro and controlled laboratory research purposes.
⚠ Research Use Only: This product is not approved for human or veterinary consumption, diagnostic, or therapeutic use.
Technical Specifications of Ipamorelin
Our Ipamorelin peptide is manufactured under stringent quality controls and analyzed using HPLC and Mass Spectrometry to support reproducible and reliable research outcomes.
| Parameter | Specification |
|---|---|
| Chemical Name | Ipamorelin Acetate |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| CAS Number | 170851-70-4 |
| Molecular Formula | C38H49N9O5 |
| Molecular Weight | 711.85 g/mol |
| Purity | ≥ 99% (HPLC verified) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water, sterile saline, or bacteriostatic water |
Mechanism of Action: Selective GHS-R1a Agonist
Ipamorelin functions as a mimetic of ghrelin, often referred to as the “hunger hormone.” It binds selectively to the Growth Hormone Secretagogue Receptor (GHS-R1a) expressed in the pituitary gland, where it triggers intracellular signaling cascades that promote the release of stored growth hormone.
Ghrelin Receptor Interaction
By mimicking the active domain of ghrelin, Ipamorelin binds to receptors on somatotroph cells and induces a pulse of GH secretion that closely resembles the body’s endogenous pulsatile rhythm. Its high receptor selectivity helps limit off-target activity in research models.
Comparison with GHRP-2 and GHRP-6
Classical GHRPs, such as GHRP-2 and GHRP-6, are potent GH secretagogues but are often associated with co-secretion of adrenocorticotropic hormone (ACTH), cortisol, and prolactin. Ipamorelin differentiates itself through its greater selectivity; it promotes GH release in pre-clinical models while demonstrating a lower tendency to elevate cortisol or prolactin and generally exhibits less orexigenic (appetite-stimulating) activity than GHRP-6.
Research Applications & Potential of Ipamorelin
Ipamorelin is a versatile tool compound in our research peptide catalog, used across multiple experimental frameworks. Current research commonly focuses on the areas below:
Growth Hormone Secretion Studies
Researchers employ Ipamorelin to investigate GH deficiency models and to map the dynamics of the hypothalamic–pituitary axis. It is frequently used to study how selective GHS-R1a stimulation influences plasma GH profiles over time.
Metabolic & Body Composition Research
Pre-clinical studies have assessed Ipamorelin in the context of nitrogen balance, lipolysis (fat breakdown), and muscle protein turnover. These investigations aim to clarify how GH secretagogues may affect catabolic and anabolic states in research subjects.
Synergistic Studies with CJC-1295
Another active line of research examines the combination of Ipamorelin with CJC-1295, a Growth Hormone Releasing Hormone (GHRH) analog. Because Ipamorelin acts at the pituitary and CJC-1295 at the hypothalamic level, researchers use this pairing to explore potential synergistic effects on GH pulsatility in experimental models. These combinations remain confined to controlled laboratory investigations.
Storage, Stability & Handling of Ipamorelin
Proper handling is critical to preserving peptide integrity throughout your research workflow.
- Lyophilized (Powder): Store at −20 °C. Stable for up to 24 months under recommended conditions.
- Reconstituted (Solution): After reconstitution (e.g., with bacteriostatic water), store at 4 °C and use within 2–4 weeks.
- Handling: Avoid repeated freeze–thaw cycles and minimize exposure to heat, air, and direct light.
Why Choose Peptides Skin as Your B2B Supplier?
As a dedicated B2B supplier, Peptides Skin is focused on providing research institutions with dependable peptide materials.
- Verified Purity: Each batch is tested to confirm >99% purity, reducing unwanted experimental variability.
- Analytical Transparency: HPLC and MS data are available via COA to verify identity and quality.
- Secure Shipping: Packaging is optimized to maintain peptide stability during transport.
- Reliable Inventory: Consistent stock and bulk options to support ongoing research programs.
Safety, Research Context & Disclaimers for Ipamorelin
Warning: Research Use Only — Not for Human Consumption.
The Ipamorelin peptide supplied by Peptides Skin is a chemical reference standard intended solely for laboratory research and development. It is not a food, or cosmetic and is not approved by the FDA or any regulatory authority for use in humans or animals.
Published pre-clinical literature has noted occasional observations such as mild headache or injection-site reactions in animal models. These findings are specific to controlled research settings and do not constitute medical advice. All handling should be performed using appropriate PPE and in accordance with institutional biosafety guidelines.
Frequently Asked Questions About Ipamorelin
What is the primary function of Ipamorelin in research?
In research settings, Ipamorelin is used to stimulate the release of growth hormone from the pituitary gland via selective activation of GHS-R1a. This allows scientists to study GH secretion dynamics with reduced influence on cortisol and prolactin compared to some other GHRPs.
How does Ipamorelin differ from CJC-1295?
Ipamorelin is a ghrelin mimetic (growth hormone secretagogue) that acts directly at the pituitary to trigger GH release. CJC-1295 is a GHRH analog that amplifies the hypothalamic signal upstream. In research, they are often studied together to explore potential synergistic effects on GH pulsatility through complementary mechanisms.
What is the shelf life of lyophilized Ipamorelin?
When stored correctly at −20 °C in its lyophilized form, Ipamorelin is generally stable for up to 24 months. After reconstitution, it should be kept at 4 °C and used within a few weeks for best stability.
Does Ipamorelin affect testosterone levels?
Ipamorelin is considered highly selective for the GH secretagogue receptor and does not directly target androgen receptors or the hypothalamic–pituitary–gonadal axis in research models. Accordingly, it is not typically studied as a direct modulator of testosterone.
Is this product suitable for human use?
No. The Ipamorelin supplied by Peptides Skin is designated strictly for in vitro and laboratory research use only. It must not be used for human administration, self-experimentation, or therapeutic purposes.