⚠️ Research Use Only (RUO): Retatrutide is not approved for human or veterinary use. Intended strictly for laboratory, analytical, and non-clinical research.

Retatrutide (LY3437943) is an investigational retatrutide research peptide designed as a triple hormone receptor agonist targeting GIP, GLP-1, and Glucagon (GCG) receptors. It is widely referenced in scientific literature focused on metabolic regulation, obesity research models, insulin sensitivity, and energy expenditure signaling.

Supplied as a ≥99% HPLC-verified lyophilized white powder, retatrutide is manufactured exclusively for controlled laboratory research environments.

What Is Retatrutide Research Peptide?

Retatrutide is a synthetic peptide compound developed for advanced metabolic and endocrine research. A detailed scientific overview of its structure and classification can be found here: Retatrutide Peptide: Structure, Classification & Research Overview .

Mechanism of Action (Research Context)

In laboratory research settings, retatrutide functions as a triple receptor agonist, activating GLP-1, GIP, and glucagon receptors simultaneously. This multi-pathway activity makes it valuable for studying complex metabolic signaling interactions.

Researchers frequently ask whether retatrutide belongs to steroid or hormone classes. This distinction is explained in detail here: Is Retatrutide a Steroid? Structural Classification & Mechanism of Action .

Retatrutide in Metabolic & Obesity Research

Retatrutide is commonly referenced in non-clinical metabolic and obesity research models, where researchers examine multi-receptor peptide signaling behavior.

• Energy balance and metabolic regulation research
• Obesity and weight-related laboratory models
• Insulin sensitivity and glucose homeostasis studies
• Multi-receptor signaling pathway investigations

Retatrutide vs Other Metabolic Research Peptides

In scientific comparisons, retatrutide is often evaluated alongside tirzepatide. While both peptides are studied in metabolic research, retatrutide remains distinct as a triple receptor agonist.

A full comparison is available here: Retatrutide vs Tirzepatide – Key Research Differences .

Product Specifications

Availability & Research Sourcing

Retatrutide is not FDA approved and is not sold as a pharmaceutical product. Information about research sourcing can be found here: Where to Buy Retatrutide for Research Purposes .

Handling, Stability, and Storage

• Storage (Lyophilized): −20°C recommended
• Reconstitution: Sterile or bacteriostatic water
• Post-Reconstitution: 2–8°C refrigeration
• Avoid: Repeated freeze–thaw cycles

Frequently Asked Questions

Is retatrutide safe?

Retatrutide is an investigational research peptide. Safety evaluation is limited to controlled non-clinical and clinical research settings.

Is retatrutide FDA approved?

No. Retatrutide is not FDA approved and is supplied strictly as a research-use-only (RUO) compound.

Is retatrutide the same as tirzepatide?

No. Retatrutide targets GLP-1, GIP, and Glucagon receptors, while tirzepatide targets only GLP-1 and GIP receptors.

Is retatrutide a steroid or hormone?

Retatrutide is not a steroid. It is a synthetic peptide developed for receptor signaling research.

Legal & Compliance Notice

Disclaimer: This product is sold strictly for laboratory research use only. Not for human consumption, medical treatment, diagnostic procedures, or veterinary use.