Tesamorelin

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog comprised of 44 amino acids. Widely recognized in the scientific community for its potential to stimulate the synthesis and release of endogenous growth hormone, this peptide is a critical tool for researchers investigating metabolic disorders, visceral adipose tissue reduction, and pituitary function.

At Peptides Skin, we provide high-purity (≥99%) Tesamorelin exclusively for in-vitro and laboratory experimentation. Our catalog is designed for qualified professionals seeking a reliable B2B supplier of stable, lyophilized research peptides.

Product Overview: High-Purity Tesamorelin

Tesamorelin (trans-3-hexenoyl-GHRH) is chemically distinct due to the addition of a trans-3-hexenoic acid group at the N-terminus. This structural modification improves the peptide's stability and half-life compared to native GHRH, allowing for more sustained receptor interaction in research subjects. It is most frequently cited in studies involving HIV-associated lipodystrophy and visceral fat accumulation.

As a leading research peptide catalog provider, we ensure every vial undergoes rigorous HPLC and Mass Spectrometry analysis to verify purity and sequence identity.

Technical Specifications & Chemical Data

Mechanism of Action: GHRH Analog

In research settings, Tesamorelin functions by binding to growth hormone-releasing hormone receptors (GHRHr) located in the anterior pituitary gland. This binding action mimics endogenous GHRH, triggering the pulsatile release of growth hormone (GH). Unlike non-specific secretagogues, Tesamorelin preserves the natural feedback loop involving Somatostatin and IGF-1 (Insulin-like Growth Factor 1).

Research indicates that this mechanism allows for an elevation in basal GH and IGF-1 levels without significantly altering glucose parameters in most non-diabetic models, making it a subject of interest for metabolic stability studies.

Primary Research Applications

Visceral Adipose Tissue (VAT) Studies

The most prominent area of research for Tesamorelin involves the reduction of visceral adipose tissue. Clinical literature (referencing FDA-approved uses in humans, which differs from our RUO context) suggests that Tesamorelin specifically targets VAT rather than subcutaneous fat. Laboratory models use this peptide to investigate pathways of lipolysis and triglyceride reduction in the abdominal cavity.

Metabolic Function & Lipodystrophy Models

Tesamorelin is extensively used in creating and treating models of lipodystrophy—a disorder characterizing abnormal fat distribution. Researchers utilize this peptide to study how GHRH analogs can modulate lipid profiles, including cholesterol and triglycerides, in subjects with compromised metabolic function.

Growth Hormone Secretion Pathways

Beyond fat metabolism, this peptide is utilized to map the pharmacokinetics of the pituitary gland. It serves as a control or variable in studies comparing the efficacy of various GHRH analogs versus Ghrelin mimetics (like Ipamorelin or GHRP-6).

Storage, Handling, and Stability

Proper handling is essential to maintain the integrity of the peptide structure.

• Lyophilized State: Store at -20°C. Stable for up to 24 months.
• Reconstituted: Once mixed with bacteriostatic water or sterile saline (for lab analysis), the solution should be kept at 4°C and used within 14–21 days. Avoid repeated freeze-thaw cycles.
• Light Sensitivity: Protect from direct light during storage.

Safety & Compliance

Peptides Skin adheres to strict regulatory guidelines. Tesamorelin is sold as a chemical reference material.

• Not for Human Use: This product is not a drug, food, or cosmetic. It is not approved by the FDA for treatment in humans when sold as a research chemical.
• Experimental Risks: Researchers should be equipped with proper PPE (gloves, goggles, lab coats) when handling lyophilized peptides.
• Ingestion Warning: Accidental ingestion or injection can cause adverse physiological reactions. Seek medical attention immediately in case of exposure.

Why Choose Peptides Skin?

As a specialized Peptides Skin distributor, we prioritize consistency and transparency. When you choose us as your partner, you receive:

• Third-Party Testing: Verification of purity and concentration.
• Secure Shipping: Discreet and temperature-controlled packaging options.
• Technical Support: Access to chemical data sheets for your documentation.

Explore our full research peptide catalog to find Tesamorelin and other GHRH analogs for your next project.

Disclaimer: The information provided above is for educational and reference purposes only. It does not constitute medical advice. The Tesamorelin supplied by Peptides Skin is strictly for in-vitro research.