GHK-Cu Peptide (Copper Tripeptide-1) | 99%+ Purity Research Grade
Introduction to GHK-Cu Peptide
GHK-Cu peptide, also known as Copper Tripeptide-1, is a naturally occurring copper complex initially identified in human plasma. This tripeptide, comprising glycyl-L-histidyl-L-lysine (GHK) bound to copper(II), exhibits a high affinity for Cu2+ ions. It is extensively utilized in research focusing on tissue remodeling, regenerative biology, and skin physiology.
At Peptides Skin, we supply premium-grade, lyophilized GHK-Cu specifically manufactured for in vitro and laboratory investigations. Our commitment emphasizes batch-to-batch consistency and analytical transparency.
Product Overview & Specifications
| Product Name | GHK-Cu (Copper Tripeptide-1) |
| Sequence | Gly-His-Lys (GHK) copper(II) complex |
| CAS Number | 49557-75-7 |
| Molecular Formula | C14H24N6O4Cu |
| Purity | ≥ 99.0% (HPLC verified) |
| Form | Lyophilized blue powder |
| Solubility | Soluble in water, saline, and common laboratory buffers |
What Is GHK-Cu Peptide?
GHK-Cu is a small peptide-copper complex found naturally in human plasma, saliva, and urine. Dr. Loren Pickart first characterized it in the 1970s as a growth-modulating factor linked to tissue repair. In biological systems, endogenous GHK-Cu levels typically decrease with age, a trend correlated with reduced regenerative capacity in various experimental models.
In laboratory research, GHK-Cu is frequently employed to investigate how copper-peptide complexes may influence gene expression patterns related to tissue repair, oxidative stress defense, and extracellular matrix remodeling. It is often described as a potential “injury signal” peptide, participating in the early phases of the repair cascade.
Key Research Applications
Scientific literature highlights multiple lines of investigation involving GHK-Cu. The following applications refer to pre-clinical and in vitro findings and are not claims of therapeutic efficacy in humans.
1. Collagen and Glycosaminoglycan Synthesis
In dermal fibroblast cultures, GHK-Cu has been reported to support the synthesis of collagen (including types I, III, and IV), elastin, and glycosaminoglycans. These matrix components are crucial for skin structure and mechanical resilience, making GHK-Cu a widely used tool in extracellular matrix and skin biology research.
2. Wound Healing & Tissue Remodeling
Pre-clinical animal models suggest that GHK-Cu may influence wound repair by modulating antioxidant enzyme levels and inflammatory mediators such as TNF-α and IL-6. It has also been investigated for potential roles in angiogenesis and the regulation of matrix metalloproteinases (MMPs) and their inhibitors, both central to tissue remodeling dynamics.
3. Hair Follicle & Skin Research
In vitro and in vivo studies have explored the impact of GHK-Cu on hair follicle biology, including follicle size and hair shaft density. Some experimental work has examined whether GHK-Cu can counteract signaling pathways associated with follicle miniaturization, though such findings remain in the research domain and do not imply clinical approval or cosmetic claims.
Storage and Handling Guidelines
Correct storage is essential to preserve the integrity and activity of the peptide complex.
- Lyophilized Powder: Store at −20 °C, dry and protected from light. Under these conditions, GHK-Cu is typically stable for 24+ months.
- Reconstituted Solution: After dissolution in bacteriostatic water or suitable buffer, store at 4 °C and use within 2–3 weeks.
- Handling: Avoid repeated freeze–thaw cycles and limit exposure to heat, air, and direct light during experimental use.
Why Choose Peptides Skin?
Peptides Skin is a specialized B2B supplier focused on high-purity research peptides and reference standards. When you select our GHK-Cu, you benefit from:
- Third-Party Testing: Each batch is verified via HPLC and Mass Spectrometry (MS) for identity and purity.
- Strict Quality Protocols: Processes are designed to minimize contaminants and enhance stability.
- B2B-Oriented Logistics: Secure, temperature-conscious shipping options and support for bulk and wholesale orders.
Safety & Research Disclaimer
WARNING: This product is a laboratory research chemical. It is not a drug, food, cosmetic, or dietary ingredient and must not be ingested, injected, or applied to human or animal skin.
Use is restricted to qualified professionals working within properly equipped laboratories. All handling should be conducted with appropriate Personal Protective Equipment (PPE) and in accordance with institutional and regulatory safety guidelines.
Frequently Asked Questions (FAQ)
What is the primary mechanism of GHK-Cu in research?
In research settings, GHK-Cu is primarily studied for its ability to complex with copper ions and influence gene expression related to tissue repair, inflammatory response, and antioxidant defense pathways. It has also been associated with the modulation of metalloproteinases and their inhibitors in extracellular matrix studies.
How should GHK-Cu peptide be stored?
Lyophilized GHK-Cu should be stored at −20 °C, away from light and moisture, where it can remain stable for up to 24 months. Once reconstituted in a suitable solvent, it should be refrigerated at 4 °C and used within a few weeks for optimal stability.
Is GHK-Cu peptide legal to purchase for research?
In most jurisdictions, GHK-Cu may be purchased legally for laboratory and research use, as it is generally not classified as a controlled substance. However, it is not approved by regulatory agencies such as the FDA for human therapeutic use or consumption, and buyers are responsible for ensuring local compliance.
Does GHK-Cu support hair growth in scientific studies?
Pre-clinical research has reported that GHK-Cu can stimulate hair follicle activity and increase follicle size in certain experimental models. These observations are limited to in vitro and animal studies and should not be interpreted as clinical or cosmetic claims.
Is this product suitable for cosmetic or personal use?
No. While GHK-Cu appears as an ingredient in some finished cosmetic formulations, the raw GHK-Cu supplied by Peptides Skin is labeled strictly for research use. It is not intended for direct cosmetic formulation or any form of personal application by end-users.