Melanotan 2 Peptide for Research (10 mg) | >99% Purity
Introduction to Melanotan 2 Peptide
Melanotan 2 peptide is a synthetic cyclic lactam analog of the naturally occurring hormone alpha-melanocyte-stimulating hormone (α-MSH). Originally developed at the University of Arizona, this heptapeptide has been the subject of extensive scientific investigation as a non-selective agonist of several melanocortin receptors.
At Peptides Skin, we provide high-purity Melanotan 2 intended strictly for laboratory and academic research. Our commitment to quality ensures that institutions and chemical researchers receive a stable, accurately quantified product for in vitro and analytical experimentation.
Product Overview: Understanding MT-2
Melanotan 2 (often abbreviated as MT-2) is chemically distinct from its predecessor, Melanotan 1, due to its cyclic lactam structure, which helps protect it from rapid enzymatic degradation. This structural modification is associated with improved stability during research use. Researchers utilize this peptide to study melanocortin signaling pathways, including interactions with MC1R, MC3R, MC4R, and MC5R in cellular and animal models.
Technical Specifications
| Property | Details |
|---|---|
| Chemical Name | Melanotan II (MT-2) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 (Melanotan II; cyclic (2–7)-lactam) |
| CAS Number | 121062-08-6 |
| Molecular Formula | C50H69N15O9 |
| Molar Mass | 1024.18 g/mol |
| Purity | ≥ 99% (HPLC analyzed) |
| Form | Lyophilized white powder |
Key Features of Our Research-Grade Melanotan 2
- High Purity: Each batch is tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure purity exceeds 99%.
- Stability: The lyophilized form supports maximum stability during transit and storage prior to reconstitution.
- Research Grade: Specifically synthesized for use in cellular studies, receptor binding assays, and chemical analysis.
- Trusted Source: Part of a curated research peptide catalog designed for institutional and professional research environments.
Research Applications & Mechanism of Action
The primary research interest in Melanotan 2 peptide concerns its potent binding affinity for melanocortin receptors. Compared with endogenous α-MSH, MT-2 exhibits a prolonged half-life under typical laboratory conditions, making it a useful tool for probing melanocortin signaling networks.
Melanogenesis & MC1R Activation
Melanotan 2 is widely studied as an agonist of the MC1 receptor (MC1R). In experimental settings, this interaction is used to model and investigate melanogenesis — the process by which pigment is produced in biological tissues. Research focuses on how MC1R activation influences the synthesis of eumelanin and downstream signaling cascades in melanocytes.
Behavioral & Metabolic Studies
Beyond pigmentation, MT-2 is commonly employed in studies involving MC3 and MC4 receptors in the central nervous system. Pre-clinical literature suggests these receptors may contribute to the regulation of energy balance and certain behavioral responses in animal models. As such, Melanotan 2 often serves as a reference compound in investigations of melanocortin-mediated metabolic and neurobehavioral pathways.
Storage and Handling Guidelines
To maintain peptide integrity throughout research workflows, proper storage is essential.
- Lyophilized (Powder): Store at −20 °C or below. Under these conditions, MT-2 is typically stable for up to 24 months.
- Reconstituted Solution: After dissolution in an appropriate solvent (e.g., bacteriostatic water), store at 4 °C and use within 2–3 weeks. Avoid repeated freeze–thaw cycles.
- Environment: Keep vials protected from direct sunlight and excessive moisture during storage and handling.
Safety Data & Research Disclaimers
Products supplied by Peptides Skin, including Melanotan 2, are intended solely for in vitro laboratory research and analytical purposes. They are not approved or intended for use as food additives, drugs, cosmetics, or household chemicals. Any physiological properties discussed reflect data from academic research and animal studies only.
Melanotan 2 has not been evaluated or approved by regulatory agencies such as the FDA for human or veterinary use. Incorrect handling can be hazardous. Only trained professionals should handle this material, following the appropriate Material Safety Data Sheet (MSDS) and institutional safety protocols.
Why Choose Peptides Skin as Your B2B Supplier?
Sourcing research chemicals requires both quality and traceability. As a dedicated B2B supplier, Peptides Skin prioritizes documentation and consistency.
- Comprehensive COA: Each lot is accompanied by a Certificate of Analysis (COA) detailing purity, identity, and analytical methods.
- Reproducibility: Controlled synthesis and QC protocols designed to reduce batch-to-batch variability.
- Logistics Support: Cold-chain aware shipping options suitable for universities, contract research organizations, and private laboratories.
Frequently Asked Questions
What is the difference between Melanotan 1 and Melanotan 2 peptide?
Melanotan 1 (afamelanotide) is a linear peptide analog of α-MSH, whereas Melanotan 2 is a cyclic lactam analog. The cyclic structure of Melanotan 2 is associated with a longer half-life and higher potency in many receptor binding assays. Researchers typically choose between them based on the specific melanocortin receptor profile and duration of action required for a given study.
How should Melanotan 2 be stored in a laboratory setting?
In its lyophilized (powder) state, Melanotan 2 should be stored at −20 °C to help maintain stability for up to 24 months. Once reconstituted for experiments, it should be kept at 4 °C, protected from light, and used within a few weeks while avoiding repeated freeze–thaw cycles.
Is Melanotan 2 approved for human use?
No. Melanotan 2 is not approved by the FDA or other regulatory authorities for human consumption, cosmetic use, or medical treatment. It is supplied strictly as a research chemical intended for in vitro work and appropriately controlled animal model studies.
What solvents are compatible with Melanotan 2?
For laboratory applications, Melanotan 2 is commonly dissolved in sterile water, bacteriostatic water, or dilute acetic acid solutions, depending on assay requirements and desired pH. Researchers should validate solvent compatibility with their specific experimental system.