PT-141 Peptide (Bremelanotide) – High Purity Research Grade
Introduction to PT-141 Peptide (Bremelanotide)
PT-141 peptide, also known scientifically as Bremelanotide, is a synthetic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). Unlike traditional agents that primarily act on the vascular system, PT-141 is extensively studied for its potential influence on the central nervous system (CNS) through the activation of specific melanocortin receptors.
As a leading offering from Peptides Skin, our PT-141 is synthesized to exceed 99% purity, helping ensure consistent and reliable data for rigorous laboratory experiments. It is commonly utilized in studies focusing on sexual function pathways, hemorrhagic shock models, and the broader physiology of the melanocortin system.
Key Features of Our Research-Grade PT-141
- High Purity (>99%): Verified via HPLC and Mass Spectrometry analysis for identity and purity, crucial for accurate research outcomes.
- Lyophilized Stability: Supplied as a freeze-dried powder to maximize shelf life and maintain structural integrity during transport and storage.
- Research Grade: Manufactured specifically for academic, biotech, and pharmaceutical R&D sectors, meeting stringent quality standards.
- Batch Consistency: Rigorous quality control ensures uniform peptide content and performance across all production lots, supporting reproducible research.
Technical Specifications of Bremelanotide (PT-141)
| Property | Details |
|---|---|
| Chemical Name | Bremelanotide (PT-141) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (cyclic 2–7 heptapeptide) |
| Molecular Formula | C50H68N14O10 |
| Molecular Weight | 1025.2 g/mol |
| CAS Number | 189691-06-3 |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or bacteriostatic water (for research preparation) |
Research Applications & Mechanism of Action of PT-141
PT-141 is a cyclic heptapeptide lactam analogue of α-MSH. Its primary utility in the research community stems from its distinct interaction with the melanocortin system, which differentiates it from agents that rely predominantly on vascular mechanisms.
Melanocortin Receptor Interaction (MC3R/MC4R Agonism)
Experimental data indicate that PT-141 acts as an agonist at specific melanocortin receptors, particularly MC3R and MC4R. These receptors are expressed in key regions of the central nervous system. By activating these pathways, PT-141 is employed in studies to investigate neural modulation of metabolism, inflammatory signaling, and sexual behavior in various animal models.
Studies on CNS-Driven Libido Pathways
Research frequently compares PT-141 to phosphodiesterase-5 (PDE5) inhibitors. While PDE5 inhibitors primarily influence vascular blood flow, PT-141 is studied for its ability to engage hypothalamic circuits and melanocortin signaling. This provides a valuable model for exploring arousal pathways that are neurological rather than solely vascular in origin. Consequently, PT-141 serves as a crucial reference compound for investigating conditions such as hypoactive sexual desire disorder (HSDD) in pre-clinical settings.
Storage & Handling Guidelines for PT-141
To maintain the integrity and efficacy of the peptide structure, proper storage and handling are paramount.
- Lyophilized Powder: Store at −20 °C. Under recommended conditions, PT-141 is typically stable for up to 3 years.
- Reconstituted Solution: Once mixed with a suitable solvent (e.g., bacteriostatic water), store at 4 °C and use within 2–3 weeks to minimize degradation. Avoid repeated freeze–thaw cycles.
- Protection: Keep vials away from direct light and excess moisture during both storage and use.
Safety Data & Essential Disclaimers
Strictly for Laboratory Research Use Only.
PT-141 supplied by Peptides Skin is a chemical reference material. It may be harmful if swallowed, inhaled, or absorbed in significant quantities and should only be handled by qualified professionals wearing appropriate Personal Protective Equipment (PPE).
- Not for use in humans or animals.
- Not a sterile medical product.
- Not a dietary supplement or cosmetic ingredient.
Researchers must comply with all applicable local, state, and federal regulations regarding the handling, storage, and disposal of research chemicals. Always consult the relevant Material Safety Data Sheet (MSDS) prior to use.
Why Choose Peptides Skin as Your B2B Research Peptide Supplier?
Finding a reliable source for high-purity research peptides can be challenging due to market variability. As a trusted B2B supplier, Peptides Skin prioritizes transparency and scientific rigor.
We provide comprehensive documentation, including Certificates of Analysis (CoA) and Mass Spectrometry reports, ensuring that the PT-141 peptide you receive precisely matches the specifications required for sensitive experimental workflows. Explore our broader research peptide catalog to identify complementary compounds for your laboratory studies.
Frequently Asked Questions (FAQ) about PT-141
What is the primary mechanism of action for PT-141 in research?
In research settings, PT-141 (Bremelanotide) is observed to act as an agonist at melanocortin-3 (MC3R) and melanocortin-4 (MC4R) receptors in the central nervous system. These receptors are associated with pathways involved in sexual arousal, energy balance, and neuroendocrine regulation.
How does PT-141 differ from PDE5 inhibitors in studies?
Unlike PDE5 inhibitors, which primarily target vascular blood flow, PT-141 is studied for its ability to act on central melanocortin pathways within the hypothalamus and related brain regions. This CNS-focused mechanism allows researchers to explore arousal and libido from a neuropeptidergic perspective rather than relying solely on hemodynamic effects.
What is the proper storage temperature for lyophilized PT-141?
Lyophilized PT-141 should be stored at −20 °C or lower to help maintain stability. Once reconstituted for laboratory work, it should be kept at 4 °C, protected from light, and used within a short time frame to avoid degradation, while minimizing freeze–thaw cycles.
Is PT-141 sold for human consumption?
No. PT-141 supplied by Peptides Skin is strictly designated for in vitro laboratory research and development. It is not approved for human or veterinary consumption, therapeutic use, self-administration, or diagnostic procedures.